Ligandrol (LGD4033)

Brief about Ligandrol

•  One of the most effective SARMs for increasing muscle mass and strength. Excellent for the charging cycle.
•  Significantly suppresses one’s testosterone levels compared to other SARMs
•  It can retain excess fluid in the muscles, which gives a somewhat edematous appearance.
•  Like other SARMs, it affects the lipid profile and may increase liver enzymes.

What is Ligandrol

This is one of the most commonly used SARMs that has undergone several human clinical trials and is already in phase 2 clinical trials.

LGD4033 was developed by Ligand Pharmaceutical for use in muscle wasting diseases such as cancer or AIDS. LGD4033 is a second generation SARM, which is an improvement over first generation SARMs such as S4. To date, Ligandrol is the second most researched SARM after Ostarine.

LGD4033 is the most effective of all SARMs in terms of building muscle. But it is also the most suppressive of one’s testosterone. Our advantage is a much longer half-life, 24 to 36 hours. This is very important because with the daily dose the concentration of this substance in the blood continues to increase every day.

Effects

•  A significant increase in muscle mass with possible fluid retention, according to Reddit users.
•  A significant increase in strength indicators. Ligandrol is one of the most effective SARMs.
•  Increased bone mineral density
•  SHBG decreased. Another property of LGD4033 is that it reduces the level of SHBG (sex hormone binding globulin). This globulin inactivates testosterone, so having less SHBG in the bloodstream means more free testosterone to do its job.

Testosterone suppression

LGD4033 inhibits testosterone production most significantly of all SARMs. For this reason, you can expect side effects such as loss of libido and other symptoms of low testosterone around week 4, although this depends on your baseline testosterone levels and sensitivity to these symptoms.  Ligandrol has a dose-dependent suppression of overall testosterone compared to baseline. In one scientific study, after completing 21 days of LGD4033, hormone levels returned to baseline by day 56, meaning PCT is mandatory.

To avoid a drop in blood testosterone as much as possible, you should take SERMs (clomiphene, tamoxifen) or testosterone / gonadotropin during the Ligandrol cycle so that the testosterone level in the blood is sufficient.

Effect on the liver

Taking Ligandrol may increase liver enzymes ALT and AST. Supplements such as NAC 600-1200 mg, TUDCA – 500 mg and ALA- 500 mg taken together or separately provide protection against this side effect.

Change in lipid profile

Although to a lesser extent than anabolic steroids, all SARMs can affect cholesterol levels to some extent. In most cases they reduce HDL (good cholesterol) levels and increase LDL (bad cholesterol) levels. During the LGD4033 cycle, you will need to take these blood tests to keep your cholesterol levels in check.

Half-life

24-36 hours

Dosage

• Minimum operating dosage (beginner) 5-10 mg
• Average dosage 10-30 mg
• Recommended maximum 40 mg
• Women 5 mg